Structural biology of Tat protein transport
نویسندگان
چکیده
منابع مشابه
The energetics of the chloroplast Tat protein transport pathway revisited.
Recently, a discussion session concerning protein trafficking in photosynthetic organisms was held at the 13th International Congress on Photosynthesis, which took place in Montreal during the week of 28 August 2004. Of particular interest was a controversy about the actual energy requirements for the so-called ‘DpH-dependent’ protein transport pathway of plant and algal thylakoid membranes. Th...
متن کاملStructural and functional characterization of human immunodeficiency virus tat protein.
Site-directed mutagenesis was used to identify functional domains present within the human immunodeficiency virus (HIV) tat protein. Transient cotransfection experiments showed that derivatives of tat protein with amino acid substitutions either at the amino-terminal end or at cysteine residue 22, 37, 27, or 25 were no longer able to transactivate HIV long terminal repeat-directed gene expressi...
متن کاملStructural biology of G protein-coupled receptors.
More than 60% of the current drugs are based on G protein-coupled receptors. Paradoxically, high-resolution structures are not available to facilitate rational drug design. Difficulties in expression, purification, and crystallization of these transmembrane receptors are the reasons for the low success rate. Recent individual and network-based technology development has significantly improved o...
متن کاملStructural biology of the PCI-protein fold
The PCI fold is based on a stack of α-helices topped with a winged-helix domain and is found in a range of proteins that form central parts of large complexes such as the proteasome lid, the COP9 signalosome, elongation factor eIF3, and the TREX-2 complex. Recent structural determinations have given intriguing insight into how these folds function both to facilitate the generation of larger pro...
متن کاملMembrane protein structural biology minireview series.
It is estimated that one-third of all proteins are integral membrane proteins, defined narrowly as proteins that completely traverse the membrane bilayer. There also exists a smaller but unknown number of monotopic membrane proteins, including prostaglandin endoperoxide H synthases, that interdigitate into a single leaflet of the lipid bilayer via a specific membrane binding domain (1). Additio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2014
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2014.03.003